Aly et al 36 synthesized a series of 1-glycosyl thio pyrimidines, annulated pyrimidines derivatives, pyrazolo [3,4-d]-pyrimidines, ditetrazolo [1,5-a,1,5'-c] pyrimidines thieno [2,3-d] pyrimidines derivative the antimicrobial were determined in vitro using cup plate and paper disc method. 3 iwona łakomska, marzena fandzloch, application of 1,2,4-triazolo[1,5-a]pyrimidines for the design of coordination compounds with interesting structures and new biological properties, coordination chemistry reviews, 2016, 327-328, 221crossref. In conclusion, the objective of the our present study was to synthesize and investigated the potent antimicrobial activities of some new (z)-2-((5-(4-hydroxybenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)amino) acid with the hope of discovering new structures that could be used as potent antimicrobial agents.
Antimicrobial activity of compound was done by the disk diffusion technique among the compound with nitrogen containing heterocyclic compounds showed the most favourable antimicrobial activity. Molecular and cellular characterization of the biological effects of ruthenium(ii) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid. J chem sci (2018) 130:31 page 3 of 12 31 scheme 1 synthesis of pyrimidine derivatives of 1,5-benzodiazepine from benzoylacetonitrile scheme 2 synthesis of pyrimidine derivatives of 1,5-benzodiazepine from pyruvonitrile.
Pyrimidine derivatives starting from 2‐amino‐3,5‐dicyano‐6‐methoxy‐4‐(4‐methoxy phenyl)pyridine via selective hydrolysis followed by reaction with formates/acid halides the resulted product is a key intermediate for the synthesis of various pyrido[2,3. A series of novel ([1,2,4]triazolo[1,5-c]quinazolin-2-ylthio)carboxylic acids 2a—d and esters 3a—l were synthesized and evaluated for antimicrobial activity alkylation of potassium 2-thio-[1,2,4]triazolo[1,5- c ]quinazoline 1 with halogenocarboxylic acids and its esters proceeded s -regioselectively. With pyridine 2-carboxylic acid & pyridine 3-carboxylic acid  but there is no report on transition metal complexes of hydrazine with pyridine-4-carboxylic acid namely isonicotinic acid.
333 h n hafez et al: simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities, acta pharm 66 (2016) 331-351 table i physical and analytical data of newly synthesized compounds. Antimicrobial activity abstract thiophosgenation of sulfonamides 1a-c in the presence of dilute hcl at room temperature furnished the isothiocyanatosulfonamides 2a-c and treatment with aromatic amines gave 1,3-disubstituted thioureas 3a,b. Aldol condensation of 192 with aromatic aldehyde in acetic acid afforded the chalcons 193, which condensed with benzoic acid hydrazide in acetic acid to give the pyrazol derivatives 194 these compounds show highest antimicrobial activity, shown in (scheme 68. As an acid, the pk a of imidazole is 145, making it less acidic than carboxylic acids, phenols, and imides, but slightly more acidic than alcohols the acidic proton is the one bound to nitrogen the acidic proton is the one bound to nitrogen. Read synthesis and antimicrobial activity of new pyrimidine derivatives incorporating 1 h ‐tetrazol‐5‐ylthio moiety, journal of heterocyclic chemistry on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Synthesis, reactions and evaluation of the antimicrobial activity of some 4-(p-halophenyl)-4h-naphthopyran, pyranopyrimidine and pyranotriazolopyrimidine derivatives. Introduction: the presence of pyrimidine ring in nucleic acid, uric acid, several vitamins, some purines, and their importance in many biological processes may explain the biological significance of such molecule in the drugs containing them. A higher alkyl ester of p-hydroxybenzoic acid (paraben) with remarkably high and broad antimicrobial activity against yeasts, moulds and bacteria at very low dosage.
A series of pyrimidine bearing 1,2,4-triazole derivatives have been synthesized and evaluated for antibacterial activity all the structures of the newly synthesized compounds have been supported by ir, â¹h-nmr, 13c-nmr, gc-ms and chn analysis most of the compounds have shown promising. Antimicrobial activity of amino acid, imidazole, and sulfonamide derivatives of pyrazolo[3,4-d]pyrimidine heteroatom chem 2004 15: 57 - 62 [crossref] , [web of science ®. Spectral and in vitro antimicrobial properties of 2-oxo-4-phenyl-6-styryl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid transition metal complexes.